Should 4F-PCCs Ever be Used In the Resuscitation of the Patient Treated with a Factor Xa Inhibitor?

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As the utilization of direct oral anticoagulants (DOACs) increases, there is a parallel increase in major bleeding events, especially intracranial hemorrhages, requiring hospitalization. Clinicians are not recognizing or distinguishing major from minor bleeding, or appropriately employing emergent options to manage major bleeding. Recent solutions for DOAC related life-threatening bleeding are under-recognized and under-utilized solutions for patients with these life-threatening emergencies. Over the last 12-18 months, nationally recognized guidelines have provided clear direction on how best to manage these types of major bleeding events. As data emerges regarding new approaches to therapy, clinicians need to be aware of these new and effective approaches and to assess the benefits and risks associated with each of these approaches. Education provided by experts from the EMCREG-International network within this program correctly and promptly address patient treatment approaches to the appropriate healthcare professionals.

This program covers reversal strategies and when to use them in the presence of a DOAC-related bleed, including in the emergent setting, and reviews the latest clinical guidelines and trial data to guide DOAC and 4-factor PCC use in the management of life-threatening bleeding.

W. Brian Gibler, MD FACEP, FACC, FAHA
President, EMCREG-International
Professor of Emergency Medicine
Director of Business Development
Department of Emergency Medicine
University of Cincinnati College of Medicine
Cincinnati, OH

John Eikelboom, MBBS, MSc
Professor, Department of Medicine
McMaster University
Ontario, Canada

Gregory J. Fermann, MD
Professor and Executive Vice Chairman
Department of Emergency Medicine
University of Cincinnati College of Medicine
Cincinnati, OH

Life-Threatening Bleeding in the Anticoagulated Patient: Is There Ever a Role for 4-Factor PCCs in the Patient Treated With DOACs?

Management of the Emergency Department Patient on Anticoagulation: The Use of Repletion and Reversal Agents

Case Study: Treatment of Severe Bleeding in the Anticoagulated Trauma Patient in the Emergency Department

Managing Life-Threatening Bleeding in the Anticoagulated Patient: What Roles Do 4-Factor PCCs Play in Resuscitation?