Dr. Brian Gibler began studying cardiac biomarkers in 1989 with the SMARTT study. This initial collaboration with other experts in the field would go on to become the genesis of EMCREG-International as a research and education network comprised of expert academic and clinical researchers in Emergency Medicine.

Several more EMCREG cardiac biomarker trials were completed as well as lead roles in the CRUSADE Quality Improvement initiave, the iTRACS ACS Registry, and the EARLY trial for eptifibitide in ACS.